Immunostimulant potential of Moringa Oleifera leaves alcoholic extract versus Oregano Essential Oil (OEO) against cyclophosphamide-induced immunosuppression in broilers chicks.
Mostafa Abdelgaber MohamedAmany Abdelbaky El-MleehRania Talat HamadIbrahim Said Abu-AlyaMohamed Hamdy El-HewaityAhmed Ragab ElbestawyAbdelrahman Mahmoud ElbagoryAhmed Saber Sayed-AhmedMabrouk Attia Abd EldaimOmnia Ibrahim ElshabrawyPublished in: Tropical animal health and production (2023)
The current study was conducted to evaluate the immunoenhancement effect of Moringa oleifera leaves alcoholic extract (MOLE) versus Oregano essential oil (OEO) against cyclophosphamide induced immunosuppression in broilers chicks. A total of a three hundred one-day-old chicks were assigned randomly into three main dietary groups, control, MOLE, and OEO for 14 days. After 14 days the three main experimental groups were subdivided into six groups, control, cyclophosphamide, MOLE, MOLE and Cyclophosphamide, OEO, and OEO and cyclophosphamide. Each group of these six groups was subdivided into three subgroups. Supplementation of broiler chicks with MOLE and OEO for 14 days significantly increased body weight compared to the control group. However, injection of broiler chicks with cyclophosphamide significantly induced body weight loss, impaired immunological response represented by decreasing total leukocytic count, differential leukocytic count, phagocytic activity, phagocytic index, and hemagglutinin inhibition titer for New Castle disease virus, lymphoid organs depletion, and increased the mortality rate. In contrast, supplementation of cyclophosphamide treated chicks with MOLE and OEO significantly reduced cyclophosphamide induced body weight loss and impaired immunological responses, as it showed significant increase in body weight, total leukocytic count, differential leukocytic count, phagocytic activity, phagocytic index, and hemagglutinin inhibition titer for New Castle disease virus, lymphoid organs proliferation, and reduced the mortality rate. This study indicated that MOLE and OEO supplementation ameliorated cyclophosphamide induced body weight loss and impaired immunological responses.
Keyphrases
- essential oil
- low dose
- high dose
- weight loss
- body weight
- high glucose
- diabetic rats
- oxidative stress
- heat stress
- bariatric surgery
- drug induced
- magnetic resonance
- type diabetes
- endothelial cells
- adipose tissue
- cardiovascular disease
- cardiovascular events
- roux en y gastric bypass
- magnetic resonance imaging
- body mass index
- signaling pathway
- anti inflammatory
- skeletal muscle