Clinically relevant profiles of myelin content changes in patients with multiple sclerosis: A multimodal and multicompartment imaging study.
Andrea LazzarottoMatteo ToniettoEmilie PoirionMarco BattagliniRaffaele PalladinoCharline BenoitVito A G RiciglianoElisabeth MaillartNicola De StefanoBruno StankoffBenedetta BodiniPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2022)
Our multimodal and multicompartment approach allows us to explore single-patient cortical and WM lesion demyelination and remyelination, and to generate clinically relevant indices of myelin repair. These indices may be used as outcome measures in clinical trials, thus increasing the chance to identify successful promyelinating treatments in patients with MS.