Assessment of Small Vessel Function Using 7T MRI in Patients With Sporadic Cerebral Small Vessel Disease: The ZOOM@SVDs Study.
Hilde van den BrinkStanley PhamJeroen C SieroTine ArtsLaurien OnkenhoutHugo J KuijfJeroen HendrikseJoanna Marguerite WardlawMartin DichgansJaco J ZwanenburgGeert Jan BiesselsPublished in: Neurology (2024)
We observed abnormalities in several aspects of small vessel function in patients with cSVD indicative of regionally increased arteriolar stiffness and decreased reactivity. Worse small vessel function also correlated with increased disease burden. These functional measures provide new mechanistic markers of sporadic cSVD.