Loss of GCN5L1 exacerbates damage in alcoholic liver disease through ferroptosis activation.

Chenxi YangYe YangXiuya HuQiqi TangJiaqi ZhangPeiyu ZhangXin LuJuan XuSai LiZhengni DongLu Zhu Lingdi Wang

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

Pharmaceutical modulation of CISD1 activity is critical for cellular iron homeostasis and ethanol-induced ferroptosis. The GCN5L1/CISD1 axis is crucial for oxidative stress and ethanol-induced ferroptosis in ALD and is a promising avenue for novel therapeutic strategies.

Keyphrases

oxidative stress
diabetic rats
cell death
high glucose
drug induced
liver injury
ischemia reperfusion injury
heat stress