Boosting the diagnostic power of amyloid-β PET using a data-driven spatially informed classifier for decision support.
Ashwin V VenkataramanWenjia BaiAlex WhittingtonJames F MyersEugenii A RabinerAnne Lingford-HughesPaul M Matthewsnull nullPublished in: Alzheimer's research & therapy (2021)
The diagnostic classification accuracy of amyloid PET was improved using an automated data-driven spatial classifier. Our classifier highlights the importance of considering the spatial variation in Aβ PET signal for optimal interpretation of scans. The algorithm now is available to be evaluated prospectively as a tool for automated clinical decision support in research settings.