DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression.

Tamar Paz-ElizurYael Leitner-DaganKerstin B MeyerBarak MarkusFederico Manuel GiorgiMartin O'ReillyHyunjin KimYentl EvgyRonen FlussLaurence S Freedman Robert Campbell RintoulBruce PonderZvi Livneh

Published in: JNCI cancer spectrum (2019)

The DNA Repair score, previously shown to be a lung cancer risk factor in the Israeli population, was validated in this independent study as a mechanism-based cancer risk biomarker and can substantially improve current lung cancer risk prediction, assisting prevention and early detection by computed tomography scanning.

Keyphrases

dna repair
dna damage
gene expression
computed tomography
dna damage response
induced apoptosis
risk factors
dna methylation
magnetic resonance imaging
high resolution
magnetic resonance
electron microscopy
signaling pathway
cell death
image quality