Mesenchymal Stem Cell-mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice.

Carolin Kitzberger Rebekka Spellerberg Yang Han Kathrin A Schmohl Christina Stauss Christian Zach Roland E Kälin Gabriele Multhoff Matthias Eiber Franz Schilling Rainer Glass Wolfgang Andreas Weber Ernst Wagner Peter J Nelson Christine Spitzweg

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

A strong tumor-selective recruitment of systemically applied MSCs into GBM was found using NIS as reporter gene followed by successful therapeutic application of radioiodide demonstrating the potential use of NIS-based MSCs as therapy vehicles as a new GBM therapy approach.

Keyphrases

mesenchymal stem cells
gene therapy
umbilical cord
bone marrow
type diabetes
stem cells
copy number
gene expression
risk assessment
metabolic syndrome
skeletal muscle
human health