CR5/CCL5 axis is linked to a poor outcome, and inhibition reduces metastasis in oral squamous cell carcinoma.
Wilfredo Alejandro González-ArriagadaRicardo D ColettaCarlo Lozano-BurgosCynthia GarcíaJaime MaripillánFrancisca Alcayaga-MirandaBastián Godínez-PachecoSebastián Oyarce-PezoaRené Martínez-FloresIsaac E GarcíaPublished in: Journal of cancer research and clinical oncology (2023)
The effects of CCR5 antagonists in OSCC have been poorly studied, and this study reports in vitro and in vivo evidence for the effects of Maraviroc in OSCC. Our results suggest that the CCR5/CCL5 axis plays a role in oral cancer behavior, and that its inhibition is a promising new therapy alternative.