Central and peripheral chemoreflexes in humans with treated hypertension.

Increased peripheral chemoreflex sensitivity is a pathogenic feature of human hypertension (HTN), while both central and peripheral chemoreflex sensitivities are reportedly augmented in animal models of HTN. Herein, we tested the hypothesis that both central and combined central and peripheral chemoreflex sensitivities are augmented in human hypertension (HTN). Fifteen HTN participants (68±5 years; mean±SD) and 13 normotensives (NT; 65±6 years) performed two modified rebreathing protocols where the partial pressure of end-tidal carbon dioxide (P ET CO 2 ) progressively increased while the partial pressure of end-tidal oxygen was clamped at either 150 mmHg (isoxic hyperoxia; central chemoreflex activation) or 50 mmHg (isoxic hypoxia; combined central and peripheral chemoreflex activation). Ventilation (V̇ E ; pneumotachometer) and muscle sympathetic nerve activity (MSNA; microneurography) were recorded, and ventilatory (V̇ E vs. P ET CO 2 slope) and sympathetic (MSNA vs. P ET CO 2 slope) chemoreflex sensitivities and recruitment thresholds (breakpoint) calculated. Global cerebral blood flow (gCBF; duplex Doppler) was measured, and the association with chemoreflex responses examined. Central ventilatory and sympathetic chemoreflex sensitivities were greater in HTN than NT (2.48±1.33 vs. 1.58±0.42 L·min -1 ·mmHg -1 , P = 0.030: 3.32±1.90 vs. 1.77±0.62 a.u.·mmHg -1 , P = 0.034, respectively), while recruitment thresholds were not different between groups. HTN and NT had similar combined central and peripheral ventilatory and sympathetic chemoreflex sensitivities and recruitment thresholds. A lower gCBF was associated with an earlier recruitment threshold for V̇ E (R 2 = 0.666, P<0.0001) and MSNA (R 2 = 0.698, P = 0.004) during isoxic hyperoxic rebreathing. These findings indicate that central ventilatory and sympathetic chemoreflex sensitivities are augmented in human HTN and perhaps suggest that targeting the central chemoreflex may help some forms of HTN. KEY POINTS: In human hypertension (HTN) increased peripheral chemoreflex sensitivity has been identified as a pathogenic feature, and in animal models of HTN, both central and peripheral chemoreflex sensitivities are reportedly augmented. In this study, the hypothesis was tested that both central and combined central and peripheral chemoreflex sensitivities are augmented in human HTN. We observed that both central ventilatory and sympathetic chemoreflex sensitivities were augmented in HTN compared to age-matched normotensive controls, but no difference was found in the combined central and peripheral ventilatory and sympathetic chemoreflex sensitivities. During central chemoreflex activation, the ventilatory and sympathetic recruitment thresholds were lower in those with lower total cerebral blood flow. These results indicate a potential contributing role of the central chemoreceptors in the pathogenesis of human HTN and support the possibility that therapeutic targeting of the central chemoreflex may help some forms of HTN. Abstract figure legend Sympathetic and cardiorespiratory responses to central chemoreflex activation, and combined central and peripheral chemoreflex activation, were assessed in people with hypertension (HTN) and normotension (NT) controls. Compared to NT, greater increases in muscle sympathetic nerve activity and minute ventilation were observed in HTN during central chemoreflex activation (hypercapnic hyperoxia). In contrast, NT and HTN had similar sympathetic and cardiorespiratory responses to combined central and peripheral chemoreflex activation (hypercapnic hypoxia).. This article is protected by copyright. All rights reserved.