Antidepressant-like and antioxidant effects of Morus nigra L. in rats subjected to the unpredictable chronic mild stress model.
Bruna Fischer MeridaJessica Lima Dos SantosLucas Henrique JungesAna Lúcia Bertarello ZeniEduardo Simão Da SilvaPublished in: Natural product research (2024)
This study aimed to evaluate the antidepressant-like and antioxidant potential of the aqueous leaf extract of Morus nigra L. in rats subjected to unpredictable chronic mild stress (UCMS). Male Wistar rats were divided into four groups, control and stressed, and treated with saline or aqueous extract of M. nigra. The dose administered was 10 mg/kg daily by gavage for 5 weeks concurrently with UCMS. M. nigra extract which showed syringic acid, quercetin, and rutin, as major phenolic compounds decreased the immobility time without changes in locomotor activity of stressed rats, in the forced swimming and open field tests, respectively. In addition, the extract diminished carbonylated proteins, lipid peroxidation, and nitrite levels in the brains of rats subjected to UCMS. These data reinforced antidepressant-like properties with the involvement of oxidative stress modulation by M. nigra extract pointing it as a possible new adjuvant treatment for depression.
Keyphrases
- oxidative stress
- anti inflammatory
- major depressive disorder
- stress induced
- diabetic rats
- ischemia reperfusion injury
- dna damage
- depressive symptoms
- nitric oxide
- induced apoptosis
- physical activity
- spinal cord injury
- early stage
- minimally invasive
- risk assessment
- sleep quality
- human health
- endoplasmic reticulum stress
- heat shock protein