Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia.
Anil KumarAdeleh Taghi KhaniCaroline DuaultSoraya AramburoAshly Sanchez OrtizSung June LeeAnthony K C ChanTinisha McDonaldMin HuangNorman J LacayoKathleen M SakamotoJianhua YuChristian HurtzMartin CarrollSarah K TasianLucy GhodaGuido MarcucciZhaohui GuSteven T RosenSaro ArmenianShai IzraeliChun-Wei ChenMichael A CaligiuriStephen J FormanHolden T MaeckerSrividya SwaminathanPublished in: Journal for immunotherapy of cancer (2023)
We find that restoration of the intrinsically suppressed IFN-I production in B-ALL underlies the therapeutic efficacy of IL-15-producing NK cells and that such NK cells represent an attractive therapeutic solution for the problem of drugging MYC in high-grade B-ALL.