Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis.
N A QuraishiN PalliyilMohamed A HassaninD D'AquinoA ShetaiwiD WalkerPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2023)
Neuroblastoma is the most common cause for MSCC in children (62.7%) followed by sarcoma (14.2%), whilst soft tissue sarcomas constituted the most frequent cause of MSCC in children > 5 years old. The majority of patients presented with motor deficit, followed by pain. In children with neuroblastoma /lymphoma, chemotherapy was the primary treatment. Early surgery should be a consideration with rapid deterioration of neurology despite chemotherapy. A multimodality approach including chemo-radiotherapy and surgery should be the treatment of choice in metastatic sarcomas. It is worth noting that multi-level laminectomy/decompression and asymmetrical radiation to the spine can lead to spinal column deformity in the future.
Keyphrases
- spinal cord
- minimally invasive
- locally advanced
- young adults
- systematic review
- end stage renal disease
- coronary artery bypass
- small cell lung cancer
- soft tissue
- early stage
- squamous cell carcinoma
- emergency department
- peritoneal dialysis
- high grade
- newly diagnosed
- chronic pain
- radiation therapy
- ejection fraction
- pain management
- chronic kidney disease
- neuropathic pain
- combination therapy
- diffuse large b cell lymphoma
- radiation induced
- acute coronary syndrome
- current status
- high resolution
- patient reported outcomes