Unusual hard metal lung disease: bronchiolocentric interstitial pneumonia.
Jen-Yu HsuF-Y ChuP-H WangM-L WuPublished in: Occupational medicine (Oxford, England) (2024)
A 38-year-old woman experienced a persistent dry cough and progressively worsening dyspnoea for 2 years. Spirometry testing revealed a moderate-to-severe restrictive abnormality. High-resolution chest computed tomography showed diffuse reticulonodular opacities. A lung biopsy disclosed alveolar parenchymal inflammation and fibrosis with bronchiolocentric features, prompting consideration of interstitial pneumonia. Following a thorough investigation of her occupational history and an on-site inspection, it was discovered that the patient had been grinding drill bits designed for printed circuit boards for 8 years, exposing her to hard metals. Mineralogical analyses confirmed excessive tungsten in urine, serum and hair, leading to a diagnosis of hard metal lung disease due to tungsten carbide-cobalt exposure. After discontinuing exposure and commencing corticosteroid therapy, her symptoms, pulmonary function and imaging showed modest improvement. This case highlights the significance of assessing occupational history in patients with interstitial pneumonia and understanding industrial hazards for accurate diagnosis and care.
Keyphrases
- high resolution
- computed tomography
- healthcare
- oxidative stress
- respiratory failure
- community acquired pneumonia
- case report
- mass spectrometry
- palliative care
- wastewater treatment
- heavy metals
- positron emission tomography
- high intensity
- stem cells
- single cell
- tandem mass spectrometry
- risk assessment
- chronic obstructive pulmonary disease
- magnetic resonance
- cystic fibrosis
- high speed
- human health
- reduced graphene oxide
- fine needle aspiration
- drinking water
- metal organic framework
- gold nanoparticles
- drug induced
- high grade
- affordable care act
- extracorporeal membrane oxygenation