Concurrent immune checkpoint inhibition and selective immunosuppressive therapy in patients with immune-related enterocolitis.

Yousef R BadranFangwen ZouSienna M DurbinBarbara E DutraHamzah Abu-SbeihAnusha S ThomasMehmet AltanJohn A ThompsonWei QiaoDonna E LeetPo-Ying LaiNora K HorickMichael A Postow David M Faleck Yinghong Wang Michael L Dougan

Published in: Journal for immunotherapy of cancer (2023)

After resolution of irEC symptoms, reinitiation of ICI with concurrent SIT is safe, reduces severe irEC recurrence, and has no negative impact on survival outcomes.

Keyphrases

locally advanced
early onset
squamous cell carcinoma
single molecule
free survival
drug induced
rectal cancer
sleep quality
radiation therapy
preterm infants