Altered subcortical and cortical brain morphology in adult women with 47,XXX: a 7-Tesla magnetic resonance imaging study.

Chaira SerrarensMaarten OtterBea C M CampfortsConstance T R M StumpelHenk JansmaThérèse A M J van AmelsvoortClaudia Vingerhoets

Published in: Journal of neurodevelopmental disorders (2022)

Results suggest that a supernumerary X chromosome in females affects subcortical and lateral ventricle volumes, and cortical surface area in adulthood. 47,XXX may serve as a suitable model for studying genetic influences on structural brain morphology across developmental stages in order to understand neurobiological mechanisms underlying cognitive and behavioural impairments.

Keyphrases

white matter
magnetic resonance imaging
resting state
multiple sclerosis
magnetic resonance
functional connectivity
copy number
pulmonary hypertension
computed tomography
depressive symptoms
pulmonary artery
mitral valve
cerebral ischemia
genome wide
heart failure
contrast enhanced
dna methylation
left ventricular