The Effect of Thiazide Diuretics on Urinary Prostaglandin E2 Excretion and Serum Sodium in the General Population.
Frank GeurtsCrissy F RudolphiAnissa PeloutoAnna C van der BurghMahdi SalihPedro Henrique Imenez SilvaRobert A FentonLayal ChakerEwout J HoornPublished in: The Journal of clinical endocrinology and metabolism (2024)
Serum sodium is lower in people with higher urinary PGE2 and PGEM excretion and this association is stronger in thiazide users. This suggests that PGE2-mediated water reabsorption regulates serum sodium, which is relevant for the pathogenesis of hyponatremia in general and thiazide-induced hyponatremia in specific.