A rare association of central hypothyroidism and adrenal insufficiency in a boy with Williams-Beuren syndrome.
Devi DayalDinesh GiriSenthil SenniappanPublished in: Annals of pediatric endocrinology & metabolism (2017)
Primary hypothyroidism related to morphological and volumetric abnormalities of the thyroid gland is one of the commonest of several endocrine dysfunctions in Williams-Beuren syndrome (WBS). We report a 10-month-old boy with WBS who presented with central hypothyroidism. During the neonatal period, he had prolonged jaundice, feeding difficulties and episodes of colic that continued during early infancy. Additionally, there was slowing of growth and mild developmental delay. He underwent surgical repair for supravalvular aortic stenosis at 6 months of age. An evaluation done to exclude cortisol deficiency before initiating levothyroxine lead to the detection of secondary adrenal insufficiency, unreported previously in WBS. In addition, insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels were low. This report of hypopituitarism in WBS indicates a need for complete evaluation of pituitary dysfunction in children with WBS.
Keyphrases
- aortic stenosis
- binding protein
- transcatheter aortic valve replacement
- ejection fraction
- growth hormone
- replacement therapy
- aortic valve replacement
- aortic valve
- transcatheter aortic valve implantation
- left ventricular
- case report
- young adults
- pi k akt
- oxidative stress
- physical activity
- smoking cessation
- loop mediated isothermal amplification
- label free
- drug induced
- cell proliferation