The impact of childhood varicella vaccination on the incidence of herpes zoster in the general population: modelling the effect of exogenous and endogenous varicella-zoster virus immunity boosting.
Christophe SauboinKatsiaryna HollPaolo BonanniAnne A GershonBernd BenninghoffStephane CarrynMargaret A BurgessPeter WutzlerPublished in: BMC infectious diseases (2019)
Assuming modest levels of endogenous boosting, the increase in HZ incidence following childhood varicella vaccination was smaller and lasted for a shorter period compared with 100%Exo-0%Endo boosting assumption. Endogenous boosting mechanism could partly explain the divergence between previous HZ-incidence projections and real-world evidence.
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