Insulin and osteocalcin: further evidence for a mutual cross-talk.
Francesco L BilottaBiagio ArcidiaconoSebastiano MessineoMarta GrecoEusebio ChiefariDomenico BrittiTomoko NakanishiDaniela Patrizia FotiAntonio BrunettiPublished in: Endocrine (2017)
Our results further support the existence of an endocrine axis between bone, where osteocalcin is produced, and pancreatic β-cells, and add new insights into the molecular details of this relationship. These findings may contribute to the understanding of osteocalcin regulation and its role in metabolism.