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Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.

Hitomi SakaiHiasto KawakamiTakeshi TeramuraYuta OnoderaElizabeth SomersKeiji FuruuchiToshimitsu UenakaRyoji KatoKazuhiko Nakagawa
Published in: Clinical and translational medicine (2022)
The ADC could be a more reasonable choice than mAb as a targeting agent for the FOLRα-expressing tumor.
Keyphrases
  • locally advanced
  • cancer therapy
  • diffusion weighted imaging
  • diffusion weighted
  • monoclonal antibody
  • squamous cell carcinoma
  • decision making
  • magnetic resonance imaging
  • binding protein
  • drug delivery
  • rectal cancer