Metal- and Solvent-Free Multicomponent Decarboxylative A3-Coupling for the Synthesis of Propargylamines: Experimental, Computational, and Biological Investigations.
Pavneet KaurBhupinder KumarKamlesh K GurjarRohtash KumarVinod KumarRakesh KumarPublished in: The Journal of organic chemistry (2020)
Decarboxylative A3-coupling of ortho-hydroxybenzaldehydes, secondary amines, and alkynoic acids is performed under catalyst and solvent-free conditions. The developed methodology provided a waste-free method for the synthesis of hydroxylated propargylamines which are versatile precursors for various bioactive heterocyclic scaffolds. The experimental and density functional theory studies revealed that the in situ-formed ortho-quinonoid intermediate (formed from ortho-hydroxybenzaldehyde and amine) undergoes a concerted Eschweiler-Clarke type decarboxylation with alkynoic acids. The synthesized compounds were evaluated for MAO-A, MAO-B, and AChE inhibitory activities as potential drug candidates for the treatment of various neurological disorders. Compound 4f was found to be the most potent and selective MAO-B (high selectivity over MAO-A) and AChE inhibitor in the series with IC50 values of 4.27 ± 0.07 and 0.79 ± 0.03 μM, respectively.
Keyphrases
- density functional theory
- room temperature
- ionic liquid
- visible light
- molecular dynamics
- heavy metals
- emergency department
- climate change
- risk assessment
- gold nanoparticles
- reduced graphene oxide
- case control
- human health
- sewage sludge
- highly efficient
- carbon dioxide
- metal organic framework
- anti inflammatory
- municipal solid waste