Login / Signup

CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma.

Igor OdintsovMichael V OrtizInna KhodosMarissa S MattarAllan J W LuiShinji KohsakaElisa De StanchinaJulia L Glade BenderMarc LadanyiRomel Somwar
Published in: Cancer research (2022)
Novel models of kinase-rearranged sarcomas show that MAPK pathway feedback activation dampens responses to tyrosine kinase inhibitors, revealing the potential of combinatorial therapies to combat these tumors.
Keyphrases
  • signaling pathway
  • protein kinase
  • oxidative stress
  • pi k akt
  • tyrosine kinase
  • high grade
  • risk assessment
  • cell proliferation
  • binding protein
  • chronic myeloid leukemia