CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma.

Igor OdintsovMichael V OrtizInna KhodosMarissa S MattarAllan J W LuiShinji KohsakaElisa De Stanchina Julia L Glade BenderMarc LadanyiRomel Somwar

Published in: Cancer research (2022)

Novel models of kinase-rearranged sarcomas show that MAPK pathway feedback activation dampens responses to tyrosine kinase inhibitors, revealing the potential of combinatorial therapies to combat these tumors.

Keyphrases

signaling pathway
protein kinase
oxidative stress
pi k akt
tyrosine kinase
high grade
risk assessment
cell proliferation
binding protein
chronic myeloid leukemia