CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma.
Igor OdintsovMichael V OrtizInna KhodosMarissa S MattarAllan J W LuiShinji KohsakaElisa De StanchinaJulia L Glade BenderMarc LadanyiRomel SomwarPublished in: Cancer research (2022)
Novel models of kinase-rearranged sarcomas show that MAPK pathway feedback activation dampens responses to tyrosine kinase inhibitors, revealing the potential of combinatorial therapies to combat these tumors.