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Disposable Microfluidic Sensor Based on Nanocellulose for Glucose Detection.

Khan Mohammad Ahsan UddinVille P JokinenFarzin JahangiriSami FranssilaOrlando J RojasSampo Tuukkanen
Published in: Global challenges (Hoboken, NJ) (2018)
Point-of-care devices that are inexpensive, disposable, and environmentally friendly are becoming increasingly predominant in the field of biosensing and biodiagnostics. Here, microfluidics is a suitable option to endow portability and minimal reagent and material consumption. Nanocellulose is introduced to manufacture microfluidic channels and as a storage and immobilization compartment of glucose oxidase. Improved enzymatic activity retention is demonstrated in a simple and disposable point-of-care diagnostic unit that is able to detect glucose from fluid matrices at 0.1 × 10-3 m concentration and in less than 10 min. It is concluded that the patterning and fluidic technologies that are possible with nanocellulose enable easily scalable multianalyte designs.
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