A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-κB Activation and Drug Resistance.

Christina MarkJay WarrickNatalie S Callander Peiman Hematti Shigeki Miyamoto

Published in: Molecular cancer research : MCR (2022)

HAPLN1 and MMP2 produced by BMSCs obtained from patients with multiple myeloma promote NF-κB activity and resistance to bortezomib toxicity in multiple myeloma cells, uncovering their potential as biomarkers or therapeutic targets to address bortezomib resistance in patients with multiple myeloma.

Keyphrases

multiple myeloma
signaling pathway
oxidative stress
induced apoptosis
lps induced
nuclear factor
endoplasmic reticulum stress
cell proliferation
binding protein
cell migration
oxide nanoparticles