The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials.

Mark C KendallLucas J AlvesKristi PenceTaif MukhdomiDaniel CroxfordGildasio S De Oliveira

Published in: Anesthesiology research and practice (2020)

The use of intraoperative methadone reduces postoperative pain when compared to morphine. In addition, the beneficial effect of methadone on postoperative pain is not attributable to an increase in postsurgical opioid consumption. Our results suggest that intraoperative methadone may be a viable strategy to reduce acute pain in surgical patients.

Keyphrases

postoperative pain
chronic pain
pain management
patients undergoing
liver failure
systematic review
respiratory failure
neuropathic pain
intensive care unit
aortic dissection
acute respiratory distress syndrome
extracorporeal membrane oxygenation