Δ(9)-tetrahydrocannabinol protects cardiac tissue against endoplasmic reticulum and oxidative stresses, apoptosis, and inflammation in rats with hyperinsulinemia.

Zeynep Mine Coskun Yazici Karolin Yanar Sema Bolkent

Published in: The Journal of pharmacy and pharmacology (2024)

Our findings suggest that THC treatment in rats with HI exhibited a significant effect in ameliorating cardiac tissue damage by improving the antioxidant defense system, inflammation, apoptosis, ERS, and oxidative stress.

Keyphrases

oxidative stress
endoplasmic reticulum
diabetic rats
ischemia reperfusion injury
dna damage
induced apoptosis
left ventricular
endoplasmic reticulum stress
heart failure
cell proliferation
cell death
signaling pathway
smoking cessation