Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer.

Ding PengGuangzhe GeYanqing GongYonghao ZhanShiming HeBao GuanYifan LiZiying XuHan HaoZhisong HeGengyan XiongCuijian ZhangYue ShiYuanyuan ZhouWeimin CiXuesong LiLiqun Zhou

Published in: Clinical epigenetics (2018)

This study provided mechanistic insights regarding the 5hmC loss in bladder cancer and a rationale for exploring the therapeutic use of vitamin C as a potential epigenetic treatment for bladder cancer.

Keyphrases

dna methylation
gene expression
muscle invasive bladder cancer
combination therapy
climate change