Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells.
Jing HuangSiyuan ChangYabin LuJing WangYang SiLijian ZhangShan ChengWen G JiangPublished in: Cancer cell international (2019)
Our study not only emphasized the importance of splicing variant for its role in EMT and cancer metastasis, but also helped to understand the possible mechanisms of the epigenetic controls for defining the levels and kinetic of gene splicing isoforms and their generations.
Keyphrases
- induced apoptosis
- small cell lung cancer
- papillary thyroid
- cell cycle arrest
- dna methylation
- epithelial mesenchymal transition
- gene expression
- genome wide
- transcription factor
- copy number
- squamous cell
- signaling pathway
- squamous cell carcinoma
- cell death
- advanced non small cell lung cancer
- oxidative stress
- cell proliferation
- histone deacetylase
- pi k akt
- childhood cancer
- lymph node metastasis