Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis.

Ming-Yue LiLi-Zhong LiuWende LiCalvin S H NgYi LiuAngel W Y KongZhili ZhaoShanshan WangHaolong QiHao JiaShucai YangJing DuXiang LongRocky L K HoErnest C W ChakInnes Y P WanTony S K MokMalcolm J UnderwoodNirmal Kumar GaliZhi NingGeorge Gong Chen

Published in: Journal of experimental & clinical cancer research : CR (2019)

Collectively, PM2.5 can function as the smoking carcinogen NNK to induce lung tumorigenesis by inhibiting 15-LOX1/15-LOX2.

Keyphrases

particulate matter
air pollution
signaling pathway
smoking cessation
low density lipoprotein
risk assessment
heavy metals