Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases.
C RuffmannF C F CalboliI BraviD GvericL K CurryA de SmithS PavlouJ L BuxtonA I F BlakemoreP TakousisS MolloyP PicciniD T DexterF RoncaroliSteve M GentlemanL T MiddletonPublished in: Neuropathology and applied neurobiology (2015)
High CLB burden is a key neuropathological substrate of dementia in LBD. Elevated cortical LB pathology and Aβ plaque deposition are both correlated with a faster progression to dementia. The higher CLB load in the temporal and parietal regions, which seems to be a distinguishing feature of DLB, may account for the shorter latency to dementia and could be mediated by the APOE ϵ4 allele.