Punicalin Alleviates OGD/R-Triggered Cell Injury via TGF-β-Mediated Oxidative Stress and Cell Cycle in Neuroblastoma Cells SH-SY5Y.
Tiansong YangQingyong WangYuanyuan QuYan LiuChuwen FengYulin WangWeibo SunZhongren SunYulan ZhuPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
Punicalin, an active component from Punica granatum L., was identified as a protective agent to alleviate the OGD/R-induced cell injury, which could exert the protective effect via TGF-β/Smad pathway-regulated oxidative stress and cell cycle arrest in SH-SY5Y cells.
Keyphrases
- cell cycle arrest
- induced apoptosis
- oxidative stress
- cell cycle
- cell death
- pi k akt
- transforming growth factor
- diabetic rats
- single cell
- endoplasmic reticulum stress
- cell proliferation
- signaling pathway
- epithelial mesenchymal transition
- cell therapy
- dna damage
- ischemia reperfusion injury
- high glucose
- stem cells
- mesenchymal stem cells
- mouse model
- drug induced