New twists on long noncoding RNAs: from mobile elements to motile cancer cells.
Tuan M NguyenSumayya AlchalabiOluwatoyosi AdewunmiAli S RopriJason I HerschkowitzJeffrey M RosenPublished in: RNA biology (2020)
The purpose of this review is to highlight several areas of lncRNA biology and cancer that we hope will provide some new insights for future research. These include the relationship of lncRNAs and the epithelial to mesenchymal transition (EMT) with a focus on transcriptional and alternative splicing mechanisms and mRNA stability through miRNAs. In addition, we highlight the potential role of enhancer e-lncRNAs, the importance of transposable elements in lncRNA biology, and finally the emerging area of using antisense oligonucleotides (ASOs) and small molecules to target lncRNAs and their therapeutic implications.
Keyphrases
- network analysis
- genome wide identification
- transcription factor
- genome wide analysis
- long non coding rna
- papillary thyroid
- binding protein
- gene expression
- epithelial mesenchymal transition
- nucleic acid
- squamous cell
- current status
- squamous cell carcinoma
- young adults
- oxidative stress
- signaling pathway
- human health
- risk assessment