Login / Signup

Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection.

James E BarrettAndrew FeberJavier HerreroMiljana TanicGareth A WilsonCharles SwantonStephan Beck
Published in: BMC bioinformatics (2017)
Detection and comparison of epialleles within multiple tumour regions enables phylogenetic analyses, identification of differentially expressed epialleles, and provides a measure of epigenetic heterogeneity. R code is available at github.com/james-e-barrett.
Keyphrases
  • single cell
  • loop mediated isothermal amplification
  • real time pcr
  • label free
  • dna methylation
  • gene expression
  • quantum dots
  • sensitive detection
  • clinical evaluation