Cardiac Arrhythmias in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Mechanistic Insights, Pathophysiology, and Outcomes.
Abdulrahman AbouzaidKhansa AliSuniya JatoiMansoor AhmedGulfam AhmadAhsan NazimAmin MehmoodiJahanzeb MalikPublished in: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2024)
Arrhythmias are increasingly recognized as severe complications of precapillary pulmonary hypertension, encompassing pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Despite their significant contribution to symptoms, morbidity, in-hospital mortality, and potentially sudden death in PAH/CTEPH, there remains a lack of comprehensive data on epidemiology, pathophysiology, and outcomes to inform the management of these patients. This review provides an overview of the latest evidence on this subject, spanning from the molecular mechanisms underlying arrhythmias in the hypertrophied or failing right heart to the clinical aspects of epidemiology, diagnosis, and treatment.
Keyphrases
- pulmonary hypertension
- pulmonary arterial hypertension
- pulmonary artery
- end stage renal disease
- risk factors
- atrial fibrillation
- congenital heart disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- heart failure
- left ventricular
- peritoneal dialysis
- polycyclic aromatic hydrocarbons
- prognostic factors
- early onset
- drug induced
- adipose tissue
- single molecule
- sleep quality
- artificial intelligence
- insulin resistance