Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer.

Ajaratu KeshinroChad VanderbiltJin K Kim Canan FiratChin-Tung ChenRona Yaeger Karuna GaneshNeil H SegalMithat Gönen Jinru Shia Zsofia K Stadler Martin R Weiser

Published in: JCO precision oncology (2021)

The association between TIL, TMB, and genetic alterations varies significantly between MSI, MSS, and mutant POLE/POLD1 colon tumors. These differences may help explain tumoral immunity and lead to predictors of response to immunotherapy.

Keyphrases

genome wide
wild type
copy number
genetic diversity
peripheral blood
gene expression
risk factors
dna methylation