The Medially-Invasive Cholesteatoma: An Aggressive Subtype of a Common Pathology.

Geoffrey C CasazzaMatthew L CarlsonClough SheltonRichard K Gurgel

Published in: The Annals of otology, rhinology, and laryngology (2020)

The medially-invasive cholesteatoma demonstrates an aggressive, endophytic growth pattern, invading into the otic capsule or through the perilabyrinthine air cells to the petrous apex. Surgical resection remains the best treatment option for medially-invasive cholesteatoma. When CSF leak is a concern, a subtotal petrosectomy with closure of the ear is often necessary.

Keyphrases

induced apoptosis
cell cycle arrest
internal carotid artery
oxidative stress
cell proliferation
cell death
combination therapy
replacement therapy
middle cerebral artery