Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling.

Friederike RemmNicolle KränkelDaniela LenerDaniel J Drucker Sieghart Sopper Christoph Brenner

Published in: Stem cells international (2018)

We identified the SDF1-CXCR4 axis as a crucial signaling pathway for endothelial regeneration after acute vascular injury. Furthermore, SDF1 can directly increase endothelial cell proliferation. Gliptin-mediated potentiation of endothelial regeneration was preserved in Glp1r-/- animals. Thus, gliptin-mediated endothelial regeneration proceeds through SDF-1/CXCR4 in a GLP1R-independent manner after acute vascular injury.

Keyphrases

stem cells
endothelial cells
cell proliferation
signaling pathway
wound healing
oxidative stress