Antidepressant amitriptyline-induced matrix metalloproteinase-9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line-derived neurotrophic factor mRNA expression in rat astroglial cells.

Hiromi AbeNaoto KajitaniMami Okada-TsuchiokaWataru OmoriMasahide YatsumotoMinoru Takebayashi

Published in: Neuropsychopharmacology reports (2019)

The current findings suggest that the pharmacological effect of antidepressant such as amitriptyline is mediated through an intracellular signaling pathway via the LPAR1/Gαi/o /Src family tyrosine kinase, which leads to MMP-9 activation and GDNF production.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
induced apoptosis
signaling pathway
major depressive disorder
cell cycle arrest
oxidative stress
pi k akt
high glucose
epithelial mesenchymal transition
endoplasmic reticulum stress
bipolar disorder
neuropathic pain
cell death