Conversion of M1 Macrophages to Foam Cells: Transcriptome Differences Determined by Sex.

Rafael Nambo-VenegasBerenice Palacios-GonzálezJaime Mas-OlivaAna Karen Aurioles-AmozurrutiaArmando Cruz-Rangel Abel Moreno Alfredo Hidalgo-Miranda Mauricio Rodríguez-DorantesFelipe Vadillo-OrtegaJuan Xicothencatl-CortesMaría Isabel Ruiz-OlmedoJuan Pablo Reyes-Grajeda

Published in: Biomedicines (2023)

During LDL internalization, male monocyte-derived M1 macrophages display more marked proinflammatory gene expression. In contrast, female M1 macrophages display a more significant number of markers associated with cell damage.

Keyphrases

gene expression
single cell
induced apoptosis
dna methylation
magnetic resonance
dendritic cells
cell cycle arrest
rna seq
genome wide
immune response
computed tomography
cell death
endoplasmic reticulum stress
cell proliferation
pi k akt