Effects of sitagliptin on ß-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta

Ayhanım Elif Müderrisoğlu Betül Rabia Erdoğan Zeynep Elif Yeşilyurt Ceren Uyar Boztaş İrem Karaçömerlioğlu Vecdi Melih Altan Ebru Arıoğlu İnan

Published in: Turkish journal of medical sciences (2021)

Our results indicate that sitagliptin treatment does not alter ß-AR-mediated relaxation in streptozotocin-diabetic rat aorta; however, it significantly stimulates the eNOS pathway. Future studies are needed to clarify the relationship between the eNOS pathway and DPP-4 inhibition.

Keyphrases

diabetic rats
high fat diet
oxidative stress
type diabetes
aortic valve
pulmonary artery
endothelial cells
nitric oxide synthase
wound healing
pi k akt
diabetic nephropathy
single molecule
adipose tissue
nitric oxide
pulmonary arterial hypertension
insulin resistance
replacement therapy