Left Ventricular Gene Expression in Heart Failure With Preserved Ejection Fraction-Profibrotic and Proinflammatory Pathways and Genes.
Bo YeAmy D BradshawJuan E AbrahanteJulie A DragonTim N HäußlerStephen P BellFuyuki HirashimaMartin M LeWinterMichael R ZileMarkus MeyerPublished in: Circulation. Heart failure (2023)
The transcriptome analysis of left ventricular myocardial samples from patients with HFpEF confirms an overabundant extracellular matrix gene expression, the basis of myocardial fibrosis, without a signature of activated proinflammatory pathways or genes.
Keyphrases
- percutaneous coronary intervention
- left ventricular
- gene expression
- extracellular matrix
- acute myocardial infarction
- genome wide
- dna methylation
- acute coronary syndrome
- coronary artery disease
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- heart failure
- aortic stenosis
- left atrial
- mitral valve
- bioinformatics analysis
- genome wide identification
- atrial fibrillation
- rna seq
- single cell
- ejection fraction
- transcatheter aortic valve replacement