6-Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata.

Sergio Vegas-Suárez Clarissa Anna Pisanò Catalina Requejo Harkaitz Bengoetxea José-Vicente Lafuente Sánchez Michele Morari Cristina Miguelez Luisa Ugedo

Published in: British journal of pharmacology (2020)

The effects of buspirone in SNr are influenced by dopamine loss and l-DOPA treatment. The present results suggest that the regulation of burst activity of the SNr induced by DA loss may be a good target to test new drugs for the treatment of PD and LID.

Keyphrases

metabolic syndrome
combination therapy
parkinson disease
deep brain stimulation
uric acid