Spatiotemporal Quantification of HER2-targeting Antibody-Drug Conjugate Bystander Activity and Enhancement of Solid Tumor Penetration.

Qing Wei Teng Yang Jiayu Zhu Ziwen Zhang Le Yang Yuchao Zhang Xiang-Dong Cheng Jiahui Chen Jinchao Wang Xuefei Tian Takaya Shimura Jianmin Fang Jie-Er Ying Mengyang Fan Peng Guo Xiangdong Cheng

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These promising preclinical data allowed us to initiate a phase I/II clinical study of coadministration of RC48 and trastuzumab in patients with malignant stomach cancer to further evaluate this treatment strategy in humans.

Keyphrases

cancer therapy
papillary thyroid
epidermal growth factor receptor
squamous cell
big data
cell therapy
drug delivery
machine learning
young adults
lymph node metastasis
tyrosine kinase