Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality.

Madeleine Carbonneau Yi Li Brenton R Prescott Chunyu Liu Tianxiao Huan Roby Joehanes Joanne M Murabito Nancy Heard- Costa Vanessa Xanthakis Daniel Levy Jiantao Ma

Published in: Journal of the American Heart Association (2024)

DNA methylation-based epigenetic age scores mediate the associations between the LE8 score and incident CVD, CVD-specific mortality, and all-cause mortality, particularly in individuals with higher genetic predisposition for older epigenetic age.

Keyphrases

dna methylation
cardiovascular disease
genome wide
gene expression
cardiovascular events
type diabetes
copy number
metabolic syndrome