Insulin signaling is preserved in skeletal muscle during early diabetic ketoacidosis.

Frederikke A FiskerThomas S VossMads V SvartUlla KampmannMikkel H VendelboMads B BengtsenEsben S LauritzenNiels Møller Niels Jessen

Published in: The Journal of clinical endocrinology and metabolism (2023)

Diabetic ketoacidosis (DKA) impairs insulin-stimulated activation of GS while insulin signal transduction to glucose transport and protein synthesis remains intact. Reversal of insulin resistance during treatment of DKA should target post-receptor mediators of glucose uptake.

Keyphrases

type diabetes
insulin resistance
glycemic control
skeletal muscle
blood glucose
high fat diet
metabolic syndrome
wound healing
polycystic ovary syndrome
weight loss