Azithromycin and Ceftriaxone Differentially Activate NLRP3 in LPS Primed Cancer Cells.

Gulcin TezcanMohammad AlsaadiShaimaa HamzaEkaterina E GaraninaEkaterina V MartynovaGulshat R ZiganshinaElina R FarukshinaAlbert Anatolyevich RizvanovSvetlana F Khaiboullina

Published in: International journal of molecular sciences (2022)

Our data suggest that Cf could suppress LPS induced NLRP3, which should be considered when selecting antibiotics for cancer treatment. In contrast, the effect of Az on LPS primed NLRP3 and the inflammatory cytokines production appears to depend on the cancer cell origin. Therefore, these data indicate that considerations are required when selecting Az for the treatment of cancer patients.

Keyphrases

inflammatory response
lps induced
electronic health record
nlrp inflammasome
big data
cystic fibrosis
anti inflammatory
machine learning
replacement therapy
smoking cessation