Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
Andrew S DavisonN StrittmatterH SutherlandA T HughesJ HughesG Bou-GhariosA M MilanR J A GoodwinL R RanganathJ A GallagherPublished in: Metabolomics : Official journal of the Metabolomic Society (2019)
Monoamine neurotransmitters in brain tissue from a murine model of AKU did not change following treatment with nitisinone. These findings have significant implications for patients with AKU as they suggest monoamine neurotransmitters are not altered following treatment with nitisinone.