Simultaneous Real-Time Detection of Pregnancy-Associated Plasma Protein-A and -A2 Using a Graphene Oxide-Based Surface Plasmon Resonance Biosensor.

Shi-Yuan Fan Nan-Fu ChiuChie-Pein ChenChia-Chen ChangChen-Yu Chen

Published in: International journal of nanomedicine (2020)

The GO-SPR biosensor could distinguish PAPP-A and PAPP-A2 from various mixed interference proteins with high sensitivity and specificity. It could potentially be used to measure PAPP-A and PAPP-A2 in clinical blood samples during pregnancy.

Keyphrases

label free
gold nanoparticles
sensitive detection
preterm birth
loop mediated isothermal amplification
protein protein
pregnant women
pregnancy outcomes
small molecule
real time pcr