Mast cells disrupt the duodenal mucosal integrity: Implications for the mechanisms of barrier dysfunction in functional dyspepsia.

Zhiming WangMenghao HaoLiping WuYumei HeXiaobin Sun

Published in: Scandinavian journal of gastroenterology (2022)

MCs disrupt duodenal barrier function by modulating the levels of TJ proteins, and the PAR-2 and ERK1/2 signaling pathways may mediate the pathogenesis of FD.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
oxidative stress
helicobacter pylori infection
cell proliferation
ulcerative colitis
gastroesophageal reflux disease