Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat.

Oskar Hougaard JefsenKristoffer HøjgaardSofie Laage ChristiansenBetina ElfvingDavid John NuttGregers WegenerHeidi Kaastrup Müller

Published in: Acta neuropsychiatrica (2019)

Psilocin and psilocybin showed no antidepressant-like effect in the FSL rats, despite a positive effect in humans. This suggests that other animal models of depression and other behavioural tests may be more appropriate for translational studies in the effects of psilocybin.

Keyphrases

major depressive disorder
depressive symptoms
oxidative stress
bipolar disorder